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Awards and Special Recognitions: Top ![]() Jackson, Desirée - Assistant Professor & Chair Email: jackson_da@tsu.edu
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Shishodia, Shishir - Assistant Professor
List Research Interest Keywords: NF-kB is an inducible and ubiquitously expressed transcription factor for genes involved in cell survival, cell adhesion, inflammation, differentiation and growth. Review Panels: Training/Instructional Capability: Selected Publications: 1. Shishodia S and Aggarwal BB (2005) Diosgenin Inhibits Osteoclastogenesis, Invasion, And Proliferation Through The Downregulation of Akt, IkB Kinase Activation And NF-kB-Regulated Gene Expression. Oncogene (in press) 2. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, and Aggarwal BB (2005) Curcumin (Diferuloylmethane) Downregulates Expression of Cell Proliferation, Antiapoptotic and Metastatic Gene Products Through Suppression of IkBa Kinase and AKT Activation. Molecular Pharmacology, Oct 2005 (epub ahead of print). 3. Shishodia S, Gutierrez AM, Lotan R, and Aggarwal BB. (2005) Inhibition of IkBa kinase by N-(4-hydroxyphenyl) retinamide downregulates NF-kB-regulated angiogenic and antiapoptotic gene products; and enhances apoptosis. Cancer Research, 65:9555-65. 4. Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman R, Bueso-Ramos CE, and Price JE (2005) Curcumin Suppresses the Paclitaxel-induced NF-kB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice. Cinical Cancer Research, 11(20):7490-8. 5. Shishodia S, Amin HM, Lai R, and Aggarwal BB. (2005) Curcumin (Diferuloylmethane) Inhibits Constitutive NF-kB Activation, Induces G1/S Arrest, Suppresses Proliferation and Induces Apoptosis in Mantle Cell Lymphoma. Biochemical Pharmacology. 70:700-713. 6. Siwak DR, Shishodia S, Aggarwal BB, and Kurzrock R (2005) Curcumin-induced antiproliferative and proapoptotic effect in melanoma cells is associated with suppression of IKK and NF-kB activity, and is independent of the B-Raf/MEK/ERK and Akt pathways. Cancer. 104:879-890. 7. Amit-Vazina M, Shishodia S, Harris D, Van Q, Weber D, Alexanian R, Talpaz M, Aggarwal BB and Estrov Z. (2005) Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. British Journal of Cancer. 93:70-80. 8. Shishodia S, Takada Y, and Aggarwal BB. (2005) Therapeutic Implications of Gene Deletion of Ligands and Receptors of Members of TNF Superfamily. Medicinal Chemistry Reviews – Online. 2(2):163-175. 9. Aggarwal BB and Shishodia S. (2004) Suppression of Nuclear Factor-kB activation pathway by spice-derived phytochemicals:reasoning for seasoning. Annals of the New York Academy of Sciences. 1030: 434-441. 10. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, and Takada Y (2004) Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies. Anticancer Research. 24(5A):2783-840. 11. Li L, Aggarwal BB, Shishodia S, Abbruzzese J, and Kurzrock R. (2004). Nuclear Factor-kB and IkB Kinase are Constitutively Active in Human Pancreatic Cells and their Down-regulation by Curcumin (diferuloyl methane) is Associated with Suppression of Proliferation and Induction of Apoptosis. Cancer. 101(10): 2351-62.. 12. Shishodia S, and Aggarwal BB. (2004) Guggulsterone Inhibits NF-kB and IkBa Kinase Activation, Suppresses Expression of Antiapoptotic Gene Products and Enhances Apoptosis. Journal of Biological Chemistry. 279(45): 47148-47158. 13. Shishodia S, and Aggarwal BB. (2004). Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Cigarette Smoke-Induced NF-kB Activation Through Inhibition of Activation of IkBa Kinase Human Non-small Cell Lung Carcinoma: Correlation with Suppression of Cyclin D1, COX-2, and Matrix Metalloproteinase-9. Cancer Research 64: 5004-5012. 14. Shishodia S, Koul D and Aggarwal BB. (2004)) Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Tumor Necrosis Factor-Induced NF-kB Activation Through Inhibition of Activation of IkBa Kinase and Akt in Human Non-small Cell Lung Carcinoma:Correlation with suppression of COX2 synthesis Journal of Immunology. 173(3):2011-22. 15. Shishodia S, and Aggarwal BB (2004) Nuclear Factor-kB: A Friend or a Foe in Cancer? Biochemical Pharmacology. 68(6), 1071-1080. 16. Shishodia S, and Aggarwal BB. (2004) Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. Cancer Treat. Res.119:139-73. 17. Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, and Aggarwal BB. (2004) Nuclear Factor-kB and STAT3 are Constitutively Active in CD138+ Cells Derived from Multiple Myeloma Patients and Their Suppression Leads to Apoptosis. Blood 103(8): 3175-3184. 18. Bueso-Ramos CE, Rocha FC, Shishodia S, Kantarjian HM, Medeiros LJ, Vadhan-Raj S, Estrov Z, Smith TL, Nguyen MH, and Aggarwal BB. (2004) High Expression of Constitutively Active Nuclear-kB relA Transcription Factor is Present in Blasts of Acute Myeloid Leukemia. Human Pathology, 35(2): 246-53 19. Bharti AC, Takada Y, Shishodia S, and Aggarwal BB. (2004) Evidence that RANK Ligand can suppress cell proliferation and induce apoptosis through activation of a Nuclear Factor-kB-independent and TRAF6-dependent mechanism. Journal of Biological Chemistry. 279, 6065-6076. 20. Donato NJ, Wu JY, Stapley J, Lin H, Arlinghaus R, Aggarwal BB, Shishodia S, Albitar M, Hayes K, Kantarjian H, and Talpaz M. (2004) Imatinib Mesylate Resistance Through BCR-ABL Independence in Chronic Myelogenous Leukemia. Cancer Research, 64(2): 672-7. 21. Ashikawa K, Shishodia S, Fokt I, Priebe W, and Aggarwal BB. (2004) Evidence That Activation of Nuclear Factor-kB Is Essential for Doxorubicin-Induced Cell Death in Myeloid and Lymphoid Cells. Biochemical Pharmacology, 67, 353-364. 22. Aggarwal BB, Takada Y, Shishodia S, Gutierrez AM, Oommen OV, Ichikawa H, Baba Y, and Kumar A. (2004) Nuclear transcription Factor NF-kB: Role in Biology and Medicine. Indian Journal of Experimental Biology. 42, 341-353. 23. Thompson MP, Aggarwal BB, Shishodia S, Estrov Z, and Kurzrock R. (2003) Autocrine lymphotoxin production in Epstein-Barr Virus (EBV)-immortalized B-cells: induction via NF-kB activation mediated by EBV-derived Latent Membrane Protein 1. Leukemia, 17:2196-2201. 24. Shishodia S, Majumdar S and Aggarwal BB. (2003) Ursolic Acid Inhibits Nuclear Factor-kB Activation Induced by Carcinogenic Agents Through Suppression of IkBa Kinase and p65 Phosphorylation: Correlation with Downregulation of COX2, MMP-9 and CyclinD1. Cancer Research 63, 4375-4383. 25. Shishodia S, Potdar P, Gairola GC and Aggarwal BB (2003) Curcumin downregulates cigarette smoke condensate-induced NF-kappa B activation through inhibition of IkBa kinase in human lung cancer cells: correlation with suppression of COX2 and MMP-9. Carcinogenesis 24(7), 1269-1279. 26. Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M. and Aggarwal BB (2003) Resveratrol blocks interleukin-1b-induced activation of the nuclear transcription factor NF-kB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood, 102(3), 987-995. 27. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S and Aggarwal BB. (2002). Trans-3,4,3’,5’-tetrahydroxystilbene (piceatannol) inhibits TNF-induced nuclear Factor-appaB activation through suppression of IkBakinase and p65 phosphorylation. Journal of Immunology.169 (11) 6490-6497. 28. Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, and Aggarwal BB. (2002) Cigarette smoke condensate activates nuclear transcription factor-kappa B through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis.23(9):1511-1518. 29. Mukhopadhyay A, Shishodia S, Suttles J, Brittingham K, Lamothe B, Nimmanapalli R, Bhalla KN, Aggarwal BB. (2002) Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors. Journal of Biological Chemistry. 277(34):30622-30628. 30. Mukhopadhyay A, Shishodia S, Fu XY, Aggarwal BB. (2002) Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha. Journal of Cellular Biochemistry. 84(4): 803-815. 31. Aggarwal BB, Shishodia S, Ashikawa K, and Bharti AC. (2002). The Role of TNF and its family members in inflammation and cancer: lessons from gene deletion. Current Drug Targets: Inflammation and Allergy, 1:327-341. 32. Shishodia S, and Aggarwal BB. (2002) Nuclear factor-kappa B activation: A question of life and death. Journal of Biochemistry Molecular Biology. 35: 28-40. 33. Shrivastava A, Shishodia S, and Sodhi A. (1998) Expression of LFA-1 adhesion molecules on cisplatin treated macrophages. Biochimica et Biophysica Acta. 1402(3): 269-276. 34. Shishodia S, Shrivastava A, and Sodhi A. (1998) Involvement of Ras and MAP kinase (ERK-1) in cisplatin-induced activation of bone marrow derived macrophages. Biochemistry and Molecular Biology International. 45(3): 527-534. 35. Shishodia S, Shrivastava A, and Sodhi A. (1998) Protein Kinase C: a potential pathway of macrophage activation with cisplatin. Immunology Letters. 61:179-186. 36. Shishodia S, Sodhi A, and Shrivastava A. (1998) Cisplatin stimulated murine bone marrow derived macrophages require Ca ions. Journal of Clinical Biochemistry and Nutrition. 24:1-12. 37. Shishodia S, Shrivastava A, and Sodhi A. (1997) Cisplatin stimulated murine bone marrow-derived macrophages require protein tyrosine phosphorylation. International Journal of Immunopharmacology. 19: 683-690. 38. Sodhi A, Shishodia S, and Shrivastava A. (1997) Cisplatin - stimulated murine bone marrow-derived macrophages secrete oncostatin M. Immunology and Cell Biology. 75: 492-496. 39. Shrivastava A, Shishodia S, and Sodhi A. (1997) Activation of murine peritoneal macrophages and macrophage cell lines P388D-1 and IC-21 with cisplatin. International Journal of Immunopathology and Immunopharmacology. 10: 13-21. Invited lectures: 03/25/2003: NF-kB as a Target for Cigarette Smoke-Induced Carcinogenesis of the Lung and Head and Neck Cancers, Bioimmunotherapy Lecture Series, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030. 11/25/2003: Identification of Novel Triterpenoids as Suppressor of Transcription Factor: Potential Role in Chemoprevention. Bioimmunotherapy Lecture Series, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030. 01/16/2004: Targeting Transcriptional Factors by Plant Polyphenols: Role in Prevention and Therapy of Cancer, Institutional Grand Rounds, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030. 11/14/2004: Curcumin derived from turmeric (Curcuma longa): a spice for all seasons. Third International Conference on Mechanisms of Action of Nutraceuticals, November 12-14, 2004, Haywood County, North Carolina. 06/17/2005: Mechanism of cigarette smoke-induced carcinogenesis and its suppression, Odyssey Mini Symposium, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030. 11/10/2005: Curcumin: The Indian Solid Gold, Supply Side West Show, (Sabinsa Corporation), The Venetian, Las Vegas, NV. Recent Proposals Written: Recent Professional Conferences Attended: Recent Training Workshops Attended: List of Professional Activities: List of Community and University Services: Awards and Special Recognitions:
Williams, Warren E. - Associate Professor
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