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Cancer Research Laboratory
Director- James W DuMond, Jr., Ph.D.
Dr. Dr James W DuMond Jr is an Assistant Professor in the Department of Biology. Dr. DuMond’s primary area of research interest is to study the effects of environmental factors on DNA repair mechanisms. More specifically, Dr DuMond’s laboratory is investigating the role of environmental estrogens on transcriptional excision repair. Previously, we have shown that diethylstilbestrol (DES) can down regulate transcriptional DNA repair in testicular Leydig cells by up to 40%. This data has been the basis for the development of a biomechanistic model for the induction of testicular cancer by environmental estrogens. As it is postulated that a loss of DNA repair will induced instability within the genome and that this instability may lead to the development of estrogen-mediated cancers. Currently, Dr DuMond’s laboratory is part of a NSF grant that is looking at the Chemical and Biological Assessment of Endocrine Disruptors in Waterways of Southeast Texas.
Dr DuMond’s laboratory is also investigating the effects of microgravity and radiation both alone and in combination on transcription DNA repair. This work is being conducted in conjunction with Texas Southern University’s NASA Center for Biotechnology and Environmental Health.
Laboratory Personnel:
Michelle Walker-Brown,PhD Natalia Harmon, MS Kate Ledbetter,MS Bita Maki,BS Joycelynn Butler,BS Monisha Scott,BS Latasha Wells,BS Eboni Thompson,BS Randa McCalla,HS
Selected Publications:
DuMond JW. The Host cell reactivation assay: a powerful tool for detecting a chemical’s ability to mediate DNA damage via an epigenetic mechanism. National Technical Association’s 2003 National Conference and Technical Career & Opportunity Fair, Orlando, FL Sept. 12, 2003
Harmon, N and DuMond, JW. Perturbation of Testicular cell proliferation using sodium arsenite. 2004 Society of Toxicology Annual Meeting, Baltimore, MD March 24th, 2004 (submitted and accepted Dec 1, 2003).
Ledbetter, K and DuMond, JW. Effects of Military Jet Fuel (JP5) on the Cell Proliferation of Testicular Mouse Cell Line (TM3). To be presented at the Society of In Vitro Biology’s annual meeting. San Francisco, CA May 24th, 2004
Walker-Brown, M and DuMond, JW. Perturbation of Leydig cell proliferation by cadmium. To be presented at the Society of In Vitro Biology’s annual meeting. San Francisco, CA May 24th, 2004
DuMond JW, and Roy D “The inhibition of DNA Repair Capacity by Stilbene Estrogen in Leydig cells: its implications in the induction of instability in the testicular genome. Mutation Research, 483(1-2): 27-33, 2001
DuMond JW, Singh, KP, and Roy D “The Biphasic Stimulation of Proliferation of Leydig Cells by Estrogen Exposure” International Journal of Oncology, 18:3, 623-628, 2001
DuMond JW, Singh, KP, and Roy D “Regulation of the growth of mouse Leydig cells by the inactive stereoisomer, 17a-estradiol: Lack of correlation between the elevated expression of ERa and difference in sensitivity to estradiol isomers.” Oncology Reports 8:4, 899-902, 2001
Spear TM, DuMond JW, Lloyd C, and Vincent JH. “An Effective Protection Factor Study of Respirators Used By Primary Lead Smelter Workers” Applied Occupational Safety and Environmental Hygiene, 15(2):235-44, 2000.
Ongoing Research Support
Title: NASA Research Center for Biotechnology and Environmental Health. Subproject: The effect of radiation and simulated microgravity on genomic stability.* Agency: NASA – University Research Center Duration:6/16/03-6/15/08 Amount: $6,000,000
Title: Attenuation of DNA repair through a perturbation of the cell cycle: A possible mechanism for the initiation of cancer by environmental estrogens. * Agency: Texas Southern University Seed Grant Duration:12/01/02-8/31/03 Amount: $18,500
Title: Multidisciplinary Assessment of Environmental Contamination in the Waterways of Southeast Texas. Agency: NSF-HBCU Duration: 3 years (6/01/04-5/31/07) Amount: $1,000,000
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