Study Findings

Aim 1:
Identify the key elements associated with aPCa among AA males and create SDOH-based interventions to potentially reduce the burden of aPCa among AA males

Aim 2:
Development of SDOH-based interventions for aPCa among AA males through community-based participatory research (CBPR)

Collaborators:

• Houston Methodist Hospital
• Sankofa Research Institute & Community Workgroup
• Community Advisory Board
• PharmD Interns

• AA males have a higher incidence of PCa (168.8 per 100,000) compared to Caucasian males (95.3 per 100,000)
• AA males (12.3%) are more likely to present with a clinically advanced stage/aggressive PCa (aPCa) at diagnosis when compared to non-Hispanic Caucasians (6.3%) and Hispanic males ((10.5%)
• Early screening for PCa improves chances for earlier stage diagnosis and reduces mortality but AA are less likely to have early screening performed

Area Deprivation Index* (ADI)

A neighborhood with a high Area Deprivation Index (ADI) is considered economically disadvantaged.

• AA Men living in an economically disadvantaged neighborhood were more likely to have aPCa
• Living in an economically disadvantaged neighborhood may increase the risk of developing aPCa**

*ADI data collected through census track/Zipcode and not individual patient report

** - Hypothesis generated by our data that would need to be confirmed against the existing literature/validated in future studies

Medications: Thiazide and Thiazide-like Diuretics*#

• AA Men taking thiazide-like diuretics were less likely to have aPCa
• Use of thiazide-like diuretics may protect against developing aPCa**

*- Medication data collected from individual patient report in medical record
#-Thiazide and thiazide-like diuretics used to treat hypertension. E.g. Hydrochlorothiazide. Sometimes called “water-pill”
** - Hypothesis generated by our data that would need to be confirmed against the existing literature/validated in future studies

Medications: Angiotensin 2 Receptor Antagonist*#

• AA Men taking angiotensin 2 receptor antagonists were less likely to have aPCa
• Use of angiotensin 2 receptor antagonists may protect against developing aPCa**

*- Medication data collected from individual patient report in medical record
#- Angiotensin 2 receptor antagonist used to treat hypertension. E.g. Losartan, valsartan, Olmesartan
** - Hypothesis generated by our data that would need to be confirmed against the existing literature/validated in future studies

Medications: Direct Vasodilators*#

• AA Men taking direct vasodilators were more likely to have aPCa
• Use of direct vasodilators may increase the risk of developing aPCa**

*- Medication data collected from individual patient report in medical record
#- Direct vasodilators used to treat hypertension. E.g. Hydralazine
** - Hypothesis generated by our data that would need to be confirmed against the existing literature/validated in future studies

• Disseminating prostate cancer educational materials among their respective circle of influence
• Sign up for TSU mobile health coach to provide prostate cancer screening
• Prostate cancer education event or webinar
• Promote prostate cancer and health education events
• Donate to support We Roar Against Prostate Cancer funds